Fiona Matthews
My programme of work covers both the methodological development and estimation of changes associated with ageing. Modelling the ageing process to correctly investigate individual differences, adjust for missing data and investigation of the correct formulation of the time process requires both good data and improved methodology. The programme covers the improvement in methodology and then application within applied scientific papers.
1. Healthy life expectancy and multi-state modelling
With: Ardo van den Hout, Venediktos Kapetanakis, Carol Jagger (Leicester) and others
- Modelling measures of healthy life expectancy using longitudinal data
- Investigation of model fit and comparison of model methodology in health life expectancy
- Investigation of missing data within multi-state models
- Understanding and relaxing the Markov assumption within modelling of healthy life expectancy
2. Cognitive modelling and modelling through the life course
With: Graciela Muniz, Eleni Bakra, MRC Lifelong Health and Ageing, MRC Centre for Causal Analysis in Translational Research, MRC Epidemiology Resource Centre, MRC Social and Public Health Sciences Unit, Scott Hofer (Oregon, USA) and others
- Investigation of individual differences in cognitive change over time, over age and the possibility of terminal decline near death
- Investigation of whether groups of individuals with similar risk profiles can be identified in cognitive ageing
- The impact of missing data on the estimation of cognitive change
- Meta-analysis of longitudinal changes across the lifecourse (PSHRN cross unit project grant)
3. MRC Collaborative Group for the Cognitive Function and Ageing Study I and II (CFAS)
With: Lu Gao, Carol Brayne (Cambridge), George Savva (Cambridge), CFAS collaborators (nationwide)
- Statistical oversight of analysis of CFAS I
- Study design, sampling, planning and co-ordination of the new CFAS II cohort
4. Applied research
With: Lu Gao, Carol Brayne (Cambridge), Blossom Stephan (Cambridge), Kathryn Richardson (Cambridge), Carol Jagger (Leicester), Simon Baron-Cohen (Cambridge), Carrie Allison (Cambridge), Paul Ince (Sheffield), Steve Wharton (Sheffield) and others
A dynamic changing programme of research centred around various aspects of ageing. Exact investigations change on a monthly basis, but are targetted primarily at the following scientific areas
- Mild cognitive impairment
- Cognition in life and findings after death
- Disability, it’s causes, incidence and recovery
- Healthy life expectancy, cognitive impairment free life expectancy, differences and risk factors
- Autism spectrum conditions and their prevalence within the population
- Frailty and co-morbidity in the older population
- Public health mental health
Links
For our publications search tool click here
For details of this research programme in 2001-2006 click here