MRC Biostatistics Unit
SURPH: Statistical methods Using data Resources to improve Population Health
Telephone number:Email Address: chris.jackson@mrc-bsu.cam.ac.uk
Other Research Theme Collaborations: PREM
Evidence synthesis and evaluation of health policies
Health policies are commonly informed using models that combine evidence from multiple sources. For example,- decision models used by NICE to recommend whether a new treatment should be funded by the health service
- models to inform policies for prevention of chronic diseases, e.g. routine mid-life health checks (paper)
- how to specify Bayesian models that allow direct data, indirect data and expert belief to be combined (paper)
- methods to compare alternative model assumptions ("structural uncertainty") (paper|paper)
- methods to combine short-term data from clinical trials with longer-term data and assumptions ("survival extrapolation") (paper)
Chris is on the editorial board of the journal Medical Decision Making for the 2018-2020 period.
Statistical computing
Developing and maintaining several R packages, including- msm for continuous-time Markov and hidden Markov models for longitudinal data, typically applied to disease progression
- flexsurv for survival analysis,
- denstrip for illustrating distributions,
- fic for focused model comparison.
Teaching
Public courses:- Introduction to Bayesian statistics using BUGS,
- Advanced Bayesian Modelling with BUGS,
- Summer school: Bayesian Methods in Health Economics
Recent presentations
- Slides on multi-state models for cost-effectiveness analysis in health economics. From a workshop on the use of R in health economic modelling. UCL, July 2018.
- Slides from the ENAR Biometrics Webinar on multi-state modelling, October 2017
Google Scholar profile
Selected Papers
Jackson, C. H., Jit, M. D., Sharples, L. D. & De Angelis, D. (2013)Calibration of complex models through Bayesian evidence synthesis: a demonstration and tutorial.Medical Decision Making 35: (2): 148-161
Lunn, D., Jackson, C., Best, N., Thomas, A. & Spiegelhalter, D. (2012)The BUGS Book: A Practical Introduction to Bayesian Analysis.
CRC Press :
Jackson, C., Bojke, L., Thompson, S. G., Claxton, K. & Sharples, L. D. (2011)A framework for addressing structural uncertainty in decision models.
Medical Decision Making 31: (4), 662-674
Jackson, C. (2011)Multi-State Models for Panel Data: The msm Package for R.
Journal of Statistical Software 38: (8)
Jackson, C. H., Sharples, L. D. & Thompson, S. G. (2010)Structural and parameter uncertainty in Bayesian cost-effectiveness models.
Journal of the Royal Statistical Society, Series C 59: (2), 233-253
Jackson, C. H., Sharples, L. D. & Thompson, S. G. (2010)Survival models in health economic evaluations: balancing fit and parsimony to improve prediction.
International Journal of Biostatistics 6: (1), Article 34
C Jackson, J Stevens, S Ren, N Latimer, L Bojke, A Manca, L Sharples (2017)Extrapolating survival from randomized trials using external data: a review of methods
Medical Decision Making 37: 377-390
H Thom, C Jackson, N Welton, L Sharples (2017)Using Parameter Constraints to Choose State Structures in Cost-Effectiveness Modelling
Pharmacoeconomics 35: (9): 951-962
C Jackson (2016)flexsurv: a platform for parametric survival modelling in R
Journal of Statistical Software 70:
Mytton, O. T., Jackson, C., Steinacher, A., Goodman, A., Langenberg, C., Griffin, S., Wareham N. & Woodcock, J. (2018)The current and potential health benefits of the National Health Service Health Check cardiovascular disease prevention programme in England: A microsimulation study
PLoS Medicine 15(3): e1002517
Jackson, C. H., Presanis, A. M., Conti, S. and De Angelis, D. (2018)Value of Information: Sensitivity Analysis and Research Prioritisation in Bayesian Evidence Synthesis
Journal of the Americal Statistical Association : (accepted for publication)