MRC Biostatistics Unit
DART: Design and Analysis of Randomised Trials
Telephone number:Email Address: martin.law [at] mrc-bsu.cam.ac.uk
Other Research Theme Collaborations: DART SURPH PREM
My previous research role involved a mixture of application and methodology that typifies the work of the Biostatistics Unit: Monitoring and analyse data from clinical trials, where the aim of these trials was to evaluate the efficacy of antibiotics in treating chronic obstructive pulmonary disease. From these trials, opportunities arose to improve the analysis of the data through novel methodology, or through novel application of existing methodology. Examples include improving treatment effect estimates when data are episodic by taking into account periods when an episode is in progress; analysing drug resistance in bacteria as a continuous, rather than dichotomous, variable, and applying informative censoring methodology to time to event data.
I am currently undertaking a PhD in the Unit, examining "m of n" Phase II trials and Simon's two-stage design.
Selected Papers
Martin Law, Dan Jackson (2015)Residual plots for linear regression models with censored outcome data: A refined method for visualising residual uncertainty.Communications in Statistics - Simulation and Computation : To appear
Simon E. Brill, Martin Law, Ethaar El-Emir, James P Allinson, Victoria Maddox, Irwin Nazareth, John R Hurst, Gavin C Donaldson, Timothy D Mchugh, Peter M A Calverley. Michael J Sweeting, Jadwiga A Wedzicha (2015)Effects of different antibiotic classes on airway bacteria in stable COPD: a randomised controlled trial.
Thorax :
Donaldson GC, Law M, Kowlessar B, Singh R, Brill SE, Allinson JP, Wedzicha JA. (2015)Impact of Prolonged Exacerbation Recovery in Chronic Obstructive Pulmonary Disease.
American Journal of Respiratory and Critical Care Medicine :