Email Address: firstname.lastname@example.org
I am a MRC Career Development Award research fellow working at both the MRC Biostatistics Unit and the Health e-Research Centre (Manchester). I also hold an honorary contract with Imperial College London. The aim of my group is to provide personalised prognostic predictions to clinicians based on their patients co-morbidities and biomarker trajectories, as determined from and provided through Electronic Health Records. We will initially concentrate on: chronic kidney disease, chronic obstructive pulmonary disease, and dementia. Using a range of modelling approaches, notably: latent class mixture models, landmarking and multi-state models.
I also have ongoing collaborations in relation to molecular markers of Alzheimer’s disease and increasing the external validity of clinical trials.
Selected PapersVoyle N, Patel H, Folarin A, Newhouse S, Johnston C, Visser PJ, Dobson RJB*, Kiddle SJ*. (2017)Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.
Journal of Alzheimer’s Disease 55 (4): 1417-1427
Kiddle SJ*, Steves CJ*, Mehta M, … , Lovestone S, Spector TD, Dobson RJB. (2015)Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.
Translational Psychiatry 5 (6): e584
Menni C*, Kiddle SJ*, Mangino M, … , Spector TD, Dobson R, Valdes AM. (2015)Circulating proteomic signatures of chronological age
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 70 (7): 809 - 816
Polanski K, Rhodes J, Hill C, … , Kiddle SJ, … , Buchanan-Wollaston V, Ott S, Denby KJ. (2014)Wigwams: identifying gene modules co-regulated across multiple biological conditions
Bioinformatics 30 (7): 962 - 970
Kiddle SJ, Windram OPF, McHattie S, Mead A, Beynon J, Buchanan-Wollaston V, Denby KJ, Mukherjee S. (2010)Temporal clustering by affinity propagation reveals transcriptional modules in Arabidopsis thaliana
Bioinformatics 26 (3): 355 - 362