MRC Biostatistics Unit
Research theme(s): Efficient Study Design
Role: MRC Investigator
Telephone number:
Email Address: thomas.jaki@mrc-bsu.cam.ac.uk
Role: MRC Investigator
Telephone number:
Email Address: thomas.jaki@mrc-bsu.cam.ac.uk
Thomas is MRC Professor of Statistics and Programme Leader in the DART theme. His work has focused on developing and evaluating novel statistical methods for clinical studies. These methods are adapted for specific applications to ensure they can be used in the pharmaceutical industry and also in public sector research institutions. His current research focuses on model-based dose-finding trials as well as Master protocols.
He is actively engaged in national and international COVID-19 efforts as a Co-Investigator the RECOVERY trial (www.recoverytrial.net), the early phase platform AGILE (www.agiletrial.net) as well as the long COVID platform HEAL-COVID (www.heal-covid.net).Selected Papers
Barnett H, Villar SS, Geys H, Jaki T. (accepted)A Novel Statistical Test for Treatment Differences in Clinical Trials using a Response Adaptive Forward Looking Gittins Index RuleBiometrics :
Horby P, Lim WS, Emberson J, Mafham M, Bell J, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B., Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie K, Haynes R, Landray MJ. (2021)Effect of Dexamethasone in Hospitalized Patients with COVID-19
New England Journal of Medicine 384: 693-704
Burnett T, Mozgunov P, Pallmann P, Villar S, Wheeler G, Jaki T. (2020)Adding flexibility to clinical trials designs: an example-based guide to the practical use of adaptive designs
BMC Medicine 18: 352
Mozgunov P, Jaki T. (2020)An information-theoretic approach for selecting arms in clinical trials
Journal of the Royal Statistical Society - Series B. 82: 1223-1247
Pallmann P, Bedding AW, Choodari-Oskooei B, Munyaradzi Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, R Sydes MR, Villar SS, Wason JMS, Weir CJ, Wheeler GM, Yap C, Jaki T. (2018)Adaptive designs in clinical trials: why use them, and how to run and report them
BMC Medicine 16: 29