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I am a statistician in the Design and Analysis of Randomised Trials (DART) group. Previously I spent 10 years studying and working in the Department of Geography King’s College London, completing a PhD in Hydrology in 2003. After completing an MSc in Medical Statistics at the London School of Hygiene and Tropical Medicine in 2014, I worked at the Department of Public Health and Primary Care, University of Cambridge on the INTERVAL randomised trial of 50,000 whole blood donors. My current role involves working on two randomised clinical trials. The Ancestry and biological Informative Markers for stratification of HYpertension: the (AIM HY) Study which is an MRC/British Heart Foundation funded study investigating whether genetic markers of ancestry can predict the best type of drug or combination of drugs for the treatment of hypertension. The AIM HY-INFORM study comprises two randomised crossover trials, each with a planned recruitment of 660 participants. The objective of the study is to test whether blood pressure response to first line anti-hypertensive treatment depends on ethnicity. The IPCAS study is a cluster randomised controlled trial sponsored by NHS Cambridgeshire and Peterborough CCG & University of Cambridge to evaluate a new model of care for stroke survivors living in the community.
Selected PapersJeremy Chataway, Jennifer Nicholas, Julie Wych, Nadine Schuerer, Ali Alsanousi, Dennis Chan, David MacManus, Kelvin Hunter, Val Anderson, Charles Bangham, Shona Clegg, Casper Nielsen, Nick Fox, David Wilkie, Virginia Calder, John Greenwood, Chris Frost and Richard Nicholas (2015)Smaller baseline brain volume and higher atrophy rate over two years is associated with poorer clinical outcomes: post hoc analysis of the MS-STAT trial in Secondary Progressive MS
Neurology 84 (14 Supplement): 259
Mukhtar O, Cheriyan J, Cockcroft J R, Collier D, Coulson J M, Dasgupta I, Faconti L, Glover G, PhDh, Heagerty A M, Khong T K, Lip G Y H, Mander A P, Marchong M N, Martin U, McDonnell B J, McEniery C M, Padmanabhan S, Saxena M, Peter J. Sever P J, Shiel J I, Wych J, Chowienczyk P J, Wilkinson I B. (2018)A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial.
American Heart Journal 204: 102-108
Stather P W, Wych J, Boyle J R. (2019)A systematic review and meta-analysis of remote ischaemic preconditioning for vascular surgery.
Journal of Vascular Surgery Volume 70, Issue 4: 1353-1363
Wych J, Grayling M G and Mander A P (in press)Sample Size Re-estimation in Crossover Trials - Application to the AIM HY-INFORM Study.