The MRC Biostatistics Unit keeps a record of all known BSU publications in line with the MRC’s Open Access Policy

Our latest published papers can be viewed using the following link

Jackson, C, Finikarides, L, Freeman, ALJ. 2022. The adverse effects of trastuzumab-containing regimes as a therapy in breast cancer: A piggy-back systematic review and meta-analysis. PLoS One 17:e0275321. PubMed PMID:36454979

Robertson, DS, Choodari-Oskooei, B, Dimairo, M, Flight, L, Pallmann, P, Jaki, T. 2022. Point estimation for adaptive trial designs I: A methodological review. Stat Med :. PubMed PMID:36451173

Mozgunov, P, Jaki, T, Gounaris, I, Goddemeier, T, Victor, A, Grinberg, M. 2022. Practical implementation of the partial ordering continual reassessment method in a Phase I combination-schedule dose-finding trial. Stat Med :. PubMed PMID:36428217

Khan, JN, Kimani, PK, Glimm, E, Stallard, N. 2022. Adjusting for treatment selection in phase II/III clinical trials with time to event data. Stat Med :. PubMed PMID:36419206

Vink, E, Davis, C, MacLean, A, Pascall, D, McDonald, SE, Gunson, R, Hardwick, HE, Oosthuyzen, W, Openshaw, PJM, Baillie, JK, Semple, MG, Ho, A, ISARIC4C Investigators . 2022. Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. Open Forum Infect Dis 9:ofac531. PubMed PMID:36381618

Surendran, P, Stewart, ID, Au Yeung, VPW, Pietzner, M, Raffler, J, Wörheide, MA, Li, C, Smith, RF, Wittemans, LBL, Bomba, L, Menni, C, Zierer, J, Rossi, N, Sheridan, PA, Watkins, NA, Mangino, M, Hysi, PG, Di Angelantonio, E, Falchi, M, Spector, TD, Soranzo, N, Michelotti, GA, Arlt, W, Lotta, LA, Denaxas, S, Hemingway, H, Gamazon, ER, Howson, JMM, Wood, AM, Danesh, J, Wareham, NJ, Kastenmüller, G, Fauman, EB, Suhre, K, Butterworth, AS, Langenberg, C. 2022. Rare and common genetic determinants of metabolic individuality and their effects on human health. Nat Med 28:2321-2332. PubMed PMID:36357675

Cooper, DJ, Lear, S, Sithole, N, Shaw, A, Stark, H, Ferris, M, CITIID-NIHR BioResource COVID-19 collaboration consortium, Bradley, J, Maxwell, P, Goodfellow, I, Weekes, MP, Seaman, S, Baker, S. 2022. Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers: a retrospective observational study. BMJ Open 12:e063159. PubMed PMID:36343994

Liou, L, Hornburg, M, Robertson, DS. 2022. Global FDR control across multiple RNAseq experiments. Bioinformatics :. PubMed PMID:36326442

Ouma, LO, Wason, JMS, Zheng, H, Wilson, N, Grayling, M. 2022. Design and analysis of umbrella trials: Where do we stand?. Front Med (Lausanne) 9:1037439. PubMed PMID:36313987

Bonaguro, L, Schulte-Schrepping, J, Carraro, C, Sun, LL, Reiz, B, Gemünd, I, Saglam, A, Rahmouni, S, Georges, M, Arts, P, Hoischen, A, Joosten, LAB, van de Veerdonk, FL, Netea, MG, Händler, K, Mukherjee, S, Ulas, T, Schultze, JL, Aschenbrenner, AC. 2022. Human variation in population-wide gene expression data predicts gene perturbation phenotype. iScience 25:105328. PubMed PMID:36310583

Seyedsalehi, A, Warrier, V, Bethlehem, RAI, Perry, BI, Burgess, S, Murray, GK. 2022. Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis. Brain :. PubMed PMID:36310536

Gkatzionis, A, Burgess, S, Newcombe, PJ. 2022. Statistical methods for cis-Mendelian randomization with two-sample summary-level data. Genet Epidemiol :. PubMed PMID:36273411

Khoo, SH, FitzGerald, R, Saunders, G, Middleton, C, Ahmad, S, Edwards, CJ, Hadjiyiannakis, D, Walker, L, Lyon, R, Shaw, V, Mozgunov, P, Periselneris, J, Woods, C, Bullock, K, Hale, C, Reynolds, H, Downs, N, Ewings, S, Buadi, A, Cameron, D, Edwards, T, Knox, E, Donovan-Banfield, I, Greenhalf, W, Chiong, J, Lavelle-Langham, L, Jacobs, M, Northey, J, Painter, W, Holman, W, Lalloo, DG, Tetlow, M, Hiscox, JA, Jaki, T, Fletcher, T, Griffiths, G, AGILE CST-2 Study Group. 2022. Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. Lancet Infect Dis :. PubMed PMID:36272432

Paterson, LM, Barker, D, Cro, S, Mozgunov, P, Phillips, R, Smith, C, Nahar, L, Paterson, S, Lingford-Hughes, AR. 2022. FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study. Trials 23:880. PubMed PMID:36258248

Barnett, H, Boix, O, Kontos, D, Jaki, T. 2022. Dose finding studies for therapies with late-onset toxicities: A comparison study of designs. Stat Med :. PubMed PMID:36250912

Van Praag, DLG, Wouters, K, Van Den Eede, F, Wilson, L, Maas, AIR, CENTER-TBI investigators and participants. 2022. Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury. Brain Spine 2:100854. PubMed PMID:36248103

Sun, BB, Loomis, SJ, Pizzagalli, F, Shatokhina, N, Painter, JN, Foley, CN, Biogen Biobank Team, Jensen, ME, McLaren, DG, Chintapalli, SS, Zhu, AH, Dixon, D, Islam, T, Ba Gari, I, Runz, H, Medland, SE, Thompson, PM, Jahanshad, N, Whelan, CD. 2022. Genetic map of regional sulcal morphology in the human brain from UK biobank data. Nat Commun 13:6071. PubMed PMID:36241887

Zannidi, D, Patel, PS, Leventea, E, Paciepnik, J, Dobson, F, Heyes, C, Goudie, RJB, Griep, LMO, Preller, J, Spillman, LN. 2022. Factors Associated with Significant Weight Loss in Hospitalised Patients with COVID-19: A Retrospective Cohort Study in a Large Teaching Hospital. Nutrients 14:. PubMed PMID:36235847

Bos, AV, van Gool, MMJ, Breedveld, AC, van der Mast, R, Marsman, C, Bouma, G, van de Wiel, MA, van Ham, SM, Mebius, RE, van Egmond, M. 2022. Fcα Receptor-1-Activated Monocytes Promote B Lymphocyte Migration and IgA Isotype Switching. Int J Mol Sci 23:. PubMed PMID:36232432

Webster, HH, Nyberg, T, Sinnathamby, MA, Aziz, NA, Ferguson, N, Seghezzo, G, Blomquist, PB, Bridgen, J, Chand, M, Groves, N, Myers, R, Hope, R, Ashano, E, Lopez-Bernal, J, De Angelis, D, Dabrera, G, Presanis, AM, Thelwall, S. 2022. Hospitalisation and mortality risk of SARS-COV-2 variant omicron sub-lineage BA.2 compared to BA.1 in England. Nat Commun 13:6053. PubMed PMID:36229438

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Additional Material

We also have a repository of Reports, Published Material, Pre-prints and Technical Reports in our Additional Material webpage.