The MRC Biostatistics Unit keeps a record of all known BSU publications in line with the MRC’s Open Access Policy

Our latest published papers can be viewed using the following link

Arnold, P, Sanaulla, S, V Hampson, L, Davis, A, Tan, J, Cowen, R, Kaleem, M, Williams, A, Wadsworth, I, Jaki, T. 2021. Study to evaluate the optimal dose of remifentanil required to ensure apnea during magnetic resonance imaging of the heart under general anesthesia. Paediatr Anaesth :. PubMed PMID:33629430

Burgess, S, Swanson, SA, Labrecque, JA. 2021. Are Mendelian randomization investigations immune from bias due to reverse causation?. Eur J Epidemiol :. PubMed PMID:33611685

Machiwenyika, JMT, Zhu, Y, Villar, SS, Mackay, JH. 2021. Trajectories of vital signs in patients with Covid-19. Resuscitation :. PubMed PMID:33609606

Ma, L, Grant, AJ, Sofronov, G. 2020. Multiple change point detection and validation in autoregressive time series data. Stat Pap (Berl) 61:1507-1528. PubMed PMID:33564212

Kjaergaard, AD, Marouli, E, Papadopoulou, A, Deloukas, P, Kuś, A, Sterenborg, R, Teumer, A, Burgess, S, Åsvold, BO, Chasman, DI, Medici, M, Ellervik, C. 2021. Thyroid function, sex hormones and sexual function: a Mendelian randomization study. Eur J Epidemiol :. PubMed PMID:33548002

Kemp, SA, Collier, DA, Datir, RP, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, IU, Roberts, DJ, Chandra, A, Temperton, N, CITIID-NIHR BioResource COVID-19 Collaboration, COVID-19 Genomics UK (COG-UK) Consortium, Sharrocks, K, Blane, E, Modis, Y, Leigh, K, Briggs, J, van Gils, M, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK. 2021. SARS-CoV-2 evolution during treatment of chronic infection. Nature :. PubMed PMID:33545711

Jackson, C, Freeman, ALJ, Szlamka, Z, Spiegelhalter, DJ. 2021. The adverse effects of bisphosphonates in breast cancer: A systematic review and network meta-analysis. PLoS One 16:e0246441. PubMed PMID:33544765

Foley, CN, Staley, JR, Breen, PG, Sun, BB, Kirk, PDW, Burgess, S, Howson, JMM. 2021. A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits. Nat Commun 12:764. PubMed PMID:33536417

Zhang, X, Theodoratou, E, Li, X, Farrington, SM, Law, PJ, Broderick, P, Walker, M, Klimentidis, YC, Rees, JMB, Houlston, RS, Tomlinson, IPM, Burgess, S, Campbell, H, Dunlop, MG, Timofeeva, M. 2021. Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study. Br J Cancer :. PubMed PMID:33510439

Zheng, H, Hampson, LV, Jaki, T. 2021. Bridging across patient subgroups in phase I oncology trials that incorporate animal data. Stat Methods Med Res :962280220986580. PubMed PMID:33501882

Bennett, M, White, S, Best, N, Mander, A. 2021. A novel equivalence probability weighted power prior for using historical control data in an adaptive clinical trial design: A comparison to standard methods. Pharm Stat :. PubMed PMID:33474798

Lyons, J, Akbari, A, Agrawal, U, Harper, G, Azcoaga-Lorenzo, A, Bailey, R, Rafferty, J, Watkins, A, Fry, R, McCowan, C, Dezateux, C, Robson, JP, Peek, N, Holmes, C, Denaxas, S, Owen, R, Abrams, KR, John, A, O'Reilly, D, Richardson, S, Hall, M, Gale, CP, Davies, J, Davies, C, Cross, L, Gallacher, J, Chess, J, Brookes, AJ, Lyons, RA. 2021. Protocol for the development of the Wales Multimorbidity e-Cohort (WMC): data sources and methods to construct a population-based research platform to investigate multimorbidity. BMJ Open 11:e047101. PubMed PMID:33468531

Mozgunov, P, Knight, R, Barnett, H, Jaki, T. 2021. Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study. Int J Environ Res Public Health 18:. PubMed PMID:33466469

Bendayan, R, Zhu, Y, Federman, AD, Dobson, RJB. 2021. Multimorbidity patterns and memory trajectories in older adults: Evidence from the English Longitudinal Study of Ageing. J Gerontol A Biol Sci Med Sci :. PubMed PMID:33449072

Wang, J, Patel, A, Wason, JMS, Newcombe, PJ. 2021. Two-stage penalized regression screening to detect biomarker-treatment interactions in randomized clinical trials. Biometrics :. PubMed PMID:33448327

Treasure, T, Macbeth, F, Farewell, V, Williams, NR, Fallowfield, L. 2021. The fallacy of large survival gains from lung metastasectomy in colorectal cancer. Lancet 397:97-98. PubMed PMID:33422259

Lotta, LA, Pietzner, M, Stewart, ID, Wittemans, LBL, Li, C, Bonelli, R, Raffler, J, Biggs, EK, Oliver-Williams, C, Auyeung, VPW, Luan, J, Wheeler, E, Paige, E, Surendran, P, Michelotti, GA, Scott, RA, Burgess, S, Zuber, V, Sanderson, E, Koulman, A, Imamura, F, Forouhi, NG, Khaw, KT, MacTel Consortium, Griffin, JL, Wood, AM, Kastenmüller, G, Danesh, J, Butterworth, AS, Gribble, FM, Reimann, F, Bahlo, M, Fauman, E, Wareham, NJ, Langenberg, C. 2021. A cross-platform approach identifies genetic regulators of human metabolism and health. Nat Genet 53:54-64. PubMed PMID:33414548

Howarth, KD, Mirza, T, Cooke, SL, Chin, SF, Pole, JC, Turro, E, Eldridge, MD, Garcia, RM, Rueda, OM, Boursnell, C, Abraham, JE, Caldas, C, Edwards, PAW. 2021. NRG1 fusions in breast cancer. Breast Cancer Res 23:3. PubMed PMID:33413557

Mozgunov, P, Paoletti, X, Jaki, T. 2021. A benchmark for dose-finding studies with unknown ordering. Biostatistics :. PubMed PMID:33409536

Grayling, MJ, Wason, JMS, Mander, AP. 2021. Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Commun Stat Theory Methods 50:18-34. PubMed PMID:33408437

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Additional Material

We also have a repository of Reports, Published Material, Pre-prints and Technical Reports in our Additional Material webpage.