This research aims to understand how the immune system is affected in different ways for those who have contracted COVID-19.
We use detailed clinical and immune phenotyping datasets, extracted from a large blood sample collected in patients with COVID-19 during the first peak of the pandemic, and followed up over 12 months. The unique patient follow-up of the study allows us to examine hypotheses about the impact of prolonged T and B lymphopenia upon recovery from disease, as well as inflammatory and metabolic changes over the course of the disease.
The project benefits from expertise in (1) infectious diseases and immunology, and (2) advanced statistical methodology for medical sciences. We use integrative statistical approaches aimed at taking full advantage of the rich laboratory and clinical data collected or to be collected as part of the programme. Altogether, this collaborative research has the potential to develop concrete advances in our scientific understanding of the long-term physical effects of COVID-19, and it may suggest new avenues for therapeutic intervention.
Preprint currently under review: https://www.medrxiv.org/content/10.1101/2021.01.11.20248765v1
Joint research with Professor Ken Smith’s group (Department of Medicine, Cambridge Immunology Network) and Professor Christopher Hess’ group (Department of Medicine, Cambridge Immunology Network & University of Basel, Switzerland)