The MRC Biostatistics Unit run a number of successful online and in-person courses in statistics on a range of topics at different levels, for statistical, clinical and other audiences.
Online courses take place through the University of Cambridge’s Moodle platform, while in-person courses normally take place in Cambridge at the East Forvie Building on the Cambridge Biomedical Campus. Further information about our courses is given below.
Upcoming Courses
Genetics in Drug Development, November 2023 – Registration is now open
Description: The majority of biologic and small molecule drugs perturb protein targets to exert their effects. With the recent explosion in the availability of large-scale genetic association data, it is increasingly feasible to identify genetic variants that proxy the effect of perturbing a protein drug target. Such leverage of genetic data thus offers an efficient and cost-effective approach for identifying drug targets and studying their effects. While this course is entirely self-contained, it follows on naturally from the Mendelian Randomization course. Participants who are interested in both topics may wish to apply for both courses.
Location: Online
Duration: 1 week, 5 live sessions (x2 courses per year)
Course Tutors: Dr Dipender Gill, (Novo Nordisk/Imperial College London), Dr Ville Karhunen (University of Oulu), Dr David Ryan (University College London), Dr Stephen Burgess (MRC Biostatistics Unit, University of Cambridge)
Upcoming course dates: 27th November – 1st December 2023
Course fee: £300 for all participants
Registration: Genetics in Drug Development | November 2023
More information: Genetics in Drug Development course (mendelianrandomization.com)
Mendelian Randomization, November 2023 – Registration is now open
Description: Studies based on Mendelian randomization are increasingly being used to distinguish causal relationships from observational associations in epidemiology and to prioritize potential targets for pharmaceutical intervention. This course intends to explain both simple and more complex statistical methods for causal inference in Mendelian randomization studies, and the instrumental variable assumptions on which they are based. The course includes several computing practicals in R.
Location: Online
Duration: 3 weeks, 4 live sessions per week (x2 courses per year)
Course Tutors: Dr Stephen Burgess (MRC Biostatistics Unit, University of Cambridge), Dr Verena Zuber, (Imperial College London), Dr Apostolos Gkatzionis (MRC Unit, University of Bristol), Dr Andrew Grant (University of Sydney), Dr Amy Mason (Cardiovascular Epidemiology Unit, University of Cambridge), Dr Dipender Gill (Novo Nordisk/Imperial College London)
Upcoming course dates: 6th November – 24th November 2023
Course fees: £200 (student registration), £380 (public sector registration), £500 (private sector registration)
Registration: Mendelian Randomization Course | November 2023
More information: Mendelian Randomization course (mendelianrandomization.com)
One-off and Past courses
Single-Agent Phase I Dose-Escalation Studies, October 2022
Description: Early phase trials are recognised to have a major impact on later phase confirmatory trials. This course presents state of the art methodology for Phase I dose-escalation studies that are delivered a mixture of lectures and practical sessions. The topics include model-based dose-escalation in-patients studies (such as Continual Reassessment Method [CRM], Bayesian logistic regression model [BLRM], Escalation with Overdose Control [EWOC]), designs incorporating multiple endpoints, and implementation of these designs in a software (specifically, R). This course is linked with the 7th Early Phase Adaptive Trials Workshop being held on Thursday 27th and Friday 28th October. It will serve as a forum for researchers to share, discuss, and exchange current methodological research and ideas in early phase trials and their application in practice. To find out more and register, click here.
Location: In-person
Duration: Monday 24th October 2022 (full day)
Course Tutors: Dr Pavel Mozgunov (MRC Biostatistics Unit, University of Cambridge) & Prof Thomas Jaki (MRC Biostatistics Unit, University of Cambridge)
Important Information: Attendees are asked to bring their own laptops with R installed for the practical sessions.
Registration: Short Course on Single-Agent Phase I Dose-Escalation Studies, October 2022 | University of Cambridge
More info: Short Course on Single-Agent Phase I Dose-Escalation Studies – MRC Biostatistics Unit (cam.ac.uk)
Bayesian Methods for Clinical Trials, 22 – 23 May 2023
Description: Bayesian statistics is an approach to data analysis, wherein prior beliefs about a certain quantity of interest can be formally incorporated and updated when new data become available. There is a big role for Bayesian statistics to play in making clinical trials more efficient. This two-day short course is designed to provide an introduction to both basic aspects and advanced features of Bayesian methods with applications to clinical trials. Day 1 will be a primer in Bayesian design and analysis of clinical trials, including fundamentals of Bayesian statistics, resemblance between Bayesian and classical trial designs, prior elicitation, and practical implementation of Bayesian designs in statistical software. Day 2 will focus on Bayesian adaptive methods for clinical trials, where modifications during the trial are enabled. The course will be a mix of lectures and practical session during which the attendees will apply learned methods in problems motivated by real clinical trials.
Location: In Person –
MRC Biostatistics Unit
East Forvie Building
Forvie Site
Robinson Way
Cambridge Biomedical Campus
Cambridge
CB2 0SR
Duration: 2 days
Course Tutors:
Dr Haiyan Zheng
Dr Pavel Mozgunov
Prof Thomas Jaki
Course fees: £300 (student registration), £460 (public sector registration), £600 (private sector registration)
Dose-finding Designs for Combination Treatments, October 2022
Description: Therapies using a combination of drugs have become the mainstream approach in many therapeutic areas. They, however, require more advanced designs to establish the best dose for further study compared to single-agent trials. This course presents novel dose-finding designs for combinations and dose-schedule trials that are delivered a mixture of lectures, practical sessions, and discussion. The topics will include:
- Model-based and model-free Phase I dual-agent and dose-schedules designs;
- Phase I/II designs for molecularly targeted agents;
- Randomised dose-escalations trials;
- Inclusion of covariates into Phase I dose-escalation;
Throughout the course, the examples of implemented in practice designs will be used to demonstrate the methodology. The workshop will involve practical sessions in R on these designs implementations and discussions on the practical aspects. By the end of the course, you will design your own combination or dose-schedule trial. This course is linked with the 7th Early Phase Adaptive Trials Workshop being held on Thursday 27th and Friday 28th October. It will serve as a forum for researchers to share, discuss, and exchange current methodological research and ideas in early phase trials and their application in practice. To find out more and register, click here.
Location: In-person
Duration: Tuesday 25th & Wednesday 26th October 2022 (two full days)
Course Tutors: Dr Pavel Mozgunov (MRC Biostatistics Unit, University of Cambridge) & Prof Thomas Jaki (MRC Biostatistics Unit, University of Cambridge)
Important Information: Attendees are asked to bring their own laptops with R installed for the practical sessions.
Registration: Short Course on Dose-finding Designs for Combination Treatments, October 2022 | University of Cambridge
More info: Short Course on Dose-finding Designs for Combination Treatments – MRC Biostatistics Unit (cam.ac.uk)
We’ll be in regular contact about all our new virtual courses and keep this page up to date. However, if you have any questions, please email: courseadmin@mrc-bsu.cam.ac.uk