Address:

MRC Biostatistics Unit,
Institute of Public Health,
University Forvie Site,
Robinson Way,
Cambridge. UK.
CB2 0SR

Telephone Number:

Email Address:

Research Interests:

• Multistate models
• General evidence synthesis
• Statistics issues in health economic modelling
• Application of statistical methods to cardiothoracic medicine and surgery

Selected Recent Publications:

Demiris N, Sharples L D. Bayesian evidence synthesis to extrapolate survival estimates in cost-effectiveness studies. Statistics in Medicine 2006; 25: 1960-1975.

Sharples L, Buxton M, Caine N, Cafferty F, Demiris N, Dyer M, Freeman C. Evaluation of ventricular assist device programme in the UK Health Technology Assessment  2006; 10:1-138.
 
Ohlssen D I, Sharples L D, Spiegelhalter D J. A hierarchical modelling framework for identifying unusual performance in health care providers. Journal of the Royal Statistical Society series A 2007; 170: 865-890.

Ohlssen DI, Sharples LD, Spiegelhalter DJ. Flexible random-effects models using Bayesian semi-parametric models: applications to institutional comparisons. Statistics in Medicine 2007; 26: 2088-2112.

Sharples L, Hughes V, Crean A, Dyer M, Buxton M, Goldstone K, Stone D for the CECaT study group. Cost-effectiveness of functional cardiac testing in the diagnosis and management of coronary artery disease: an RCT of stress echocardiography, cardiac magnetic resonance imaging or SPECT as the initial test compared with angiography (CECaT) . Health Technology Assessment  2007;11:1-136.

Titman A C, Sharples L D. A general goodness-of-fit test for Markov and hidden Markov models. Statistics in Medicine 2008;27:2177-2195.

Jackson C H, Thompson S G, Sharples L D. Accounting for  uncertainty in health economic decision models using model averaging. Journal of the Royal Statistical Society series A. 2009; 172:383-404.

Titman A, Rogers C A, Bonser R S, Banner N R, Sharples L D. Disease-specific Survival Benefit Of Lung Transplantation In Adults: A National Cohort Study. American Journal of Transplantation. (in press 2009).

Titman A, Sharples L. Model diagnostics for multistate models. Statistical Methods in Medical Research (in press 2010).

Jackson C H, Sharples L D, Thompson S G. Structural and parameter uncertainty in Bayesian cost-effectiveness models. Journal of the Royal Statistical Society series C  (in press 2009).