During this two-day hybrid workshop organised by the MRC Biostatistics Unit and sponsored by the NIHR - clinicians, patient representatives, and statisticians will share their perspectives and expertise on the implementation of adaptive and Bayesian clinical trials in real trials.
Description:
The first day will be primarily dedicated to talks by clinicians and patient representatives on their views and experiences of innovative clinical trial design in various therapeutic areas. These will be followed by lay talks from statisticians on the general principles of innovative designs and available guidance of their implementation.
The second day will be primarily dedicated to a series of case studies on implementation of innovative designs in practice. These will be co-presented by researchers from the MRC Biostatistics Unit, clinical trial units’ and industry statisticians. The topics will cover:
- Dose-finding trials (monotherapy, combinations, dose-schedule studies)
- Basket and platform trials
- Biomarker trials
- Bayesian Dynamic Borrowing Trials
These case studies originate from Dr Pavel Mozgunov’s NIHR Advanced Fellowship focusing on bringing innovative statistical methods to practice. The talks will focus on the high-level idea of the contribution of novel statistical methods to trial efficient and patients’ benefit and will be accessible by non-statisticians.
Programme:
A programme will be published on this web page soon.
Audience and Participation:
The participation of clinicians and patient representatives with experience of taking part in clinical trials is particularly encouraged, especially for Day 1.
Members of the CTUs and patient groups are eligible for free-attendance (funded by the NIHR) – please contact Dr Pavel Mozgunov (pavel.mozgunov@mrc-bsu.cam.ac.uk) before registering using the link below. Certain expenses for patient representatives can also be covered – please also contact Pavel for further details.
Confirmed Speakers:
- Prof Deborah Ashby (Professor of Statistics, Imperial College London)
- Dr Sean Ewings (Head of Statistics, Southampton Clinical Trial Unit)
- Prof Amanda Farrin (Professor of Clinical Trials, Leeds Clinical Trials Research Unit)
- Prof Richard FitzGerald (Professor of Experimental Pharmacology, University of Liverpool)
- Dr Julia Geronimi (Principal Translational Statistics Scientist, Servier)
- Dr Burak Kürsad Günhan (Senior Principal Biostatistician, Merck KGaA)
- Prof Thomas Jaki (Professor of Statistics, University of Cambridge)
- Prof Saye Khoo (Professor of Infectious Diseases, University of Liverpool)
- Andrew Kightley (Patient and Public Representative)
- Dr Alexander Murley (Lecturer in Neurology, University of Cambridge)
- Prof Xavier Paoletti (Professor of Statistics, Institute Curie)
- Dr Marie-Karelle Riviere (Statistical Methodologist Director, Saryga, France)
- Dr Louise Stanton (Principal Statisitcian, Southampton Clinical Trial Unit)
- Dr Stefan Symeonides (Medical Oncologist, University of Edinburgh and CRUK)
- Dr Alex Wright-Hughes (Principal Statistician, Leeds Clinical Trials Research Unit)
- Prof Christina Yap (Professor of Statistics, Institute for Cancer Research)
The event is a part of Dr Pavel Mozgunov’s NIHR Advanced Fellowship.