Summary
I am an NIHR Advanced Fellow (2025-2030) with a research focus on statistical methods for digital outcome measures in clinical trials. Digital devices - such as smartwatches that track physical activity - offer novel ways to measure health outcomes throughout people’s daily lives, while reducing the need for clinic visits. However, these innovative measures also present many statistical challenges. These include validation of novel digital outcomes, analysis of data at different levels of granularity, and complex patterns of missing data. The aim of my fellowship is to develop and apply statistical methods which address these challenges.
Videos
- webinar about our latest work on 8 Methodological questions for Digital Outcome Measures
- short introductory video on missing data issues for accelerometer data
Selected Publications
- Tackney, MS., Villar, S. and Carpenter, J. (2024) ‘Unleashing the Full Potential of Digital Endpoints: Eight Questions that Need Attention’, BMC Med 22, 413 (2024). 10.1186/s12916-024-03590-x
- Tackney, MS., Steele, Newman, J., Fritzsche, Lucivero, F., Khadjesari, Z., Lynch, J., Abbott, Barber, V., Carpenter, J., Copsey, B., Davies, EH., Dixon, WG., Fox, L., González, Griffiths, J., Hinchliffe, Kolanko, M., McGagh, D., Rodriguez, A., Roussos, So, Stanton, L., Toshner, M., Varian, F., Williamson, P., Yimer, BB. and Villar, S. ‘Digital Endpoints in Clinical Trials: Emerging Themes from a Multi-stakeholder Knowledge Exchange Event’, Trials 25, 521 (2024). 10.1186/s13063-024-08356-7
- Tackney, MS., Williamson, E., Cook, DG., Limb, E., Harris, T. and Carpenter, J.. (2023) ‘Multiple imputation approaches for epoch-level accelerometer data in trials’, Statistical methods in medical research, 10(32). 10.1177/0962280223118851
- Tackney, MS., Morris, T., White, I., Leyrat, C., Diaz-Ordaz, K. and Williamson, E.. (2023) ‘A comparison of covariate adjustment approaches under model misspecification in individually randomized trials.’, Trials, 24(1). 10.1186/s13063-022-06967-6
- Tackney, MS., Cook, DG., Stahl, D., Ismail, K., Williamson, E. and Carpenter, J.. (2021) ‘A framework for handling missing accelerometer outcome data in trials.’, Trials, 22(1). 10.1186/s13063-021-05284-8
See more on Google Scholar.
