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MRC Biostatistics Unit

 

Summary

I am a biostatistician funded by National Health Service Blood and Transplant to address problems in fields of broad relevance to their work. I am particularly interested in the development and application of statistical methods to answer questions in genetics, haematology and transfusion. NHSBT supports seven other research groups in Cambridge led by Rebecca Cardigan, Willem Ouwehand, Cedric Ghevaert  Emanuele di Angelantonio, Nick Matheson, Nick Gleadall and Simón Méndez-Ferrer.


Research

With Sara Trompeter (UCLH), Simon Stanworth (Oxford), Nick Gleadall, Marie Chion, Folarin Oyebolu and others (Cambridge) I am involved in the Haem-Match project which aims to improve the allocation of donated blood to patients using genetically inferred blood types. We collaborate with Mart Janssen, of the Netherland’s blood service Sanquin on this work.

In the past, I have been heavily involved in research into the genetic basis for population variation in blood cell phenotypes. I am currently pursuing investigation of platelet function phenotypes with Kate Downes (Addenbrookes) and Ernest Turro (Mount Sinai, New York).


Teaching

I am responsible for coordinating the Health Data Science stream of the new MPhil in Population Health Sciences, a course offered jointly by the Department of Public Health and Primary Care, the MRC Epidemiology Unit and the MRC Biostatistics Unit. The Health Data Science stream offers courses in advanced biostatistics, Bayesian statistics, machine learning, causal inference, genetic epidemiology, geostatistics and infectious disease modelling. Applications are welcome from excellent students with a background in quantitative subjects like mathematics, engineering, physics and computer science, but also students who are specialists in the biological sciences and medicine. If you are considering applying you might like to click here.


Administration

I am member of the Scientific Advisory Board of the NIHR Cambridge Bioresource and the Degree Committee of the Faculties of Clinical Medicine and Veterinary Medicine.


University and College Union

I am a Departmental Rep. and Membership Secretary for the Cambridge branch of UCU.

Senior Lecturer
William Astle